Sensitivity of Platelets to Prostaglandins in Patients with Coronary Artery Disease
نویسندگان
چکیده
The platelet sensitivity to the antiaggregatory prostaglandins (PGE1, 13,14-dihydro-PGE1, and 5,6-dihydro-PGE3) was studied in patients with coronary artery disease. Platelets of healthy subjects were used as control. The sensitivity was tested in vitro by inhibiting the adenosine diphosphate-induced platelet aggregation with these prostaglandins of various concentrations. In the patients the antiaggregatory potency of the prostaglandins was significantly lower than in healthy subjects.
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تاریخ انتشار 2001